PAPERS OF THE 132ND ASA ANNUAL MEETING Adjuvant Chemotherapy With FOLFOX for Primary Colorectal Cancer Is Associated With Increased Somatic Gene Mutations and Inferior Survival in Patients Undergoing Hepatectomy for Metachronous Liver Metastases

نویسندگان

  • Andreas Andreou
  • Dipen M. Maru
  • Junichi Shindoh
  • Steven A. Curley
  • Christopher Garrett
  • Michael J. Overman
  • Thomas A. Aloia
چکیده

Adjuvant Chemotherapy With FOLFOX for Primary Colorectal Cancer Is Associated With Increased Somatic Gene Mutations and Inferior Survival in Patients Undergoing Hepatectomy for Metachronous Liver Metastases Andreas Andreou, MD,∗ Scott Kopetz, MD,† Dipen M. Maru, MD,‡ Su S. Chen, MD,§ Giuseppe Zimmitti, MD,∗ Antoine Brouquet, MD,∗ Junichi Shindoh, MD,∗ Steven A. Curley, MD,∗ Christopher Garrett, MD,† Michael J. Overman, MD,† Thomas A. Aloia, MD,∗ and Jean-Nicolas Vauthey, MD∗

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

بررسی اثر شیمی درمانی کمکی در مرحله IIکانسرهای کولورکتال

Background: Colorectal cancer is the most common malignant gastrointestinal cancer and the fourth most common cancer throughout the world. Disease staging is performed to select the treatment method. In this interventional study we evaluated the effect of adjuvant chemotherapy on local recurrence, distant metastasis and three-year disease free survival in patients with stage 2 colorectal cancer...

متن کامل

Significance of poor performance status after resection of colorectal liver metastases

BACKGROUND Performance status (PS) is known as one of the strongest prognostic factors for survival in metastatic colorectal cancer patients. The aim of the present study was to analyze factors associated with poor PS assessed after resection for colorectal liver metastases and the impact on survival. METHODS All patients undergoing curative resection for colorectal liver metastases between 2...

متن کامل

A 5-year recurrence-free survivor with over ten colorectal liver metastases undergoing FOLFOX plus bevacizumab followed by two-stage hepatectomy

A 62-year-old male was admitted because of lower left abdominal pain and diarrhea. The patient was diagnosed with rectal cancer and multiple liver metastases. First, the laparoscopic Hartmann operation with a D3 lymph node dissection was performed. After five cycles of folinic acid, 5-fluorouracil and oxaliplatin (FOLFOX) and bevacizumab, and one additional FOLFOX, the tumor markers dramaticall...

متن کامل

“En bloc” caudate lobe and inferior vena cava resection following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal and liver metastasis of colorectal cancer

There are diverse protocols to manage patients with recurrent disease after primary cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis. We describe a case of metachronous liver metastasis after CRS and HIPEC for colorectal cancer, successfully treated with a selective metastectomy and partial graft of the inferior vena cava. A 35-yea...

متن کامل

A Successfully Resected Case of Recurrent Lung and Liver Metastases of Rectal Cancer Treated with XELIRI + Bevacizumab Therapy

It has been reported that many colorectal cancer (CRC) patients with synchronous or metachronous liver metastases underwent surgery subsequent to neoadjuvant combination chemotherapy with folinic acid, fluorouracil, and oxaliplatin (FOLFOX), folinic acid, fluorouracil, and irinotecan (FOLFIRI), or capecitabine and oxaliplatin (XELOX). However, there are very few reports of the use of capecitabi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2012